207 MLB Players debut on April 21
| # | Player | debut Date |
|---|---|---|
| 1. | Jim Adams | 4/21/1890 |
| 2. | Bill Bailey | 4/21/1911 |
| 3. | Steve Barber | 4/21/1960 |
| 4. | Curt Barclay | 4/21/1957 |
| 5. | Ginger Beaumont | 4/21/1899 |
| 6. | Heinz Becker | 4/21/1943 |
| 7. | Brad Bergesen | 4/21/2009 |
| 8. | Jesse Biddle | 4/21/2018 |
| 9. | Ewell Blackwell | 4/21/1942 |
| 10. | Johnny Blatnik | 4/21/1948 |
| 11. | Mike Blyzka | 4/21/1953 |
| 12. | Tim Bogar | 4/21/1993 |
| 13. | Jorge Bonifacio | 4/21/2017 |
| 14. | David Bote | 4/21/2018 |
| 15. | Bob Bowman | 4/21/1939 |
| 16. | Jackie Brandt | 4/21/1956 |
| 17. | Steve Brodie | 4/21/1890 |
| 18. | Alton Brown | 4/21/1951 |
| 19. | Bob Brown | 4/21/1930 |
| 20. | Sam Brown | 4/21/1906 |
| 21. | Ken Burkhart | 4/21/1945 |
| 22. | Tom Burr | 4/21/1914 |
| 23. | Harry Byrd | 4/21/1950 |
| 24. | Milt Byrnes | 4/21/1943 |
| 25. | Soup Campbell | 4/21/1940 |
| 26. | Archie Campbell | 4/21/1928 |
| 27. | Don Cardwell | 4/21/1957 |
| 28. | Rodolfo Castro | 4/21/2021 |
| 29. | Bob Chakales | 4/21/1951 |
| 30. | Tom Cheney | 4/21/1957 |
| 31. | Shin-Soo Choo | 4/21/2005 |
| 32. | Tim Christman | 4/21/2001 |
| 33. | Herb Cobb | 4/21/1929 |
| 34. | Louis Coleman | 4/21/2011 |
| 35. | Shano Collins | 4/21/1910 |
| 36. | Clint Conatser | 4/21/1948 |
| 37. | Ben Conroy | 4/21/1890 |
| 38. | Leo Cristante | 4/21/1951 |
| 39. | William Cuevas | 4/21/2016 |
| 40. | Guy Curtright | 4/21/1943 |
| 41. | Vince Dailey | 4/21/1890 |
| 42. | Curt Davis | 4/21/1934 |
| 43. | Jody Davis | 4/21/1981 |
| 44. | Jim Delsing | 4/21/1948 |
| 45. | Tod Dennehey | 4/21/1923 |
| 46. | Mel Deutsch | 4/21/1946 |
| 47. | Jim Devlin | 4/21/1873 |
| 48. | Argenis Diaz | 4/21/2010 |
| 49. | Leo Dickerman | 4/21/1923 |
| 50. | Pat Dillard | 4/21/1900 |
| 51. | Atley Donald | 4/21/1938 |
| 52. | Len Dondero | 4/21/1929 |
| 53. | Danny Dorn | 4/21/2015 |
| 54. | John Douglas | 4/21/1945 |
| 55. | Tom Dowse | 4/21/1890 |
| 56. | Bill Duggleby | 4/21/1898 |
| 57. | Grant Dunlap | 4/21/1953 |
| 58. | Roy Easterwood | 4/21/1944 |
| 59. | Al Eckert | 4/21/1930 |
| 60. | Doc Edwards | 4/21/1962 |
| 61. | Jack Egbert | 4/21/2009 |
| 62. | Jumbo Elliott | 4/21/1923 |
| 63. | Bill Endicott | 4/21/1946 |
| 64. | George Estock | 4/21/1951 |
| 65. | Oscar Estrada | 4/21/1929 |
| 66. | Chuck Estrada | 4/21/1960 |
| 67. | Thairo Estrada | 4/21/2019 |
| 68. | Bill Evans | 4/21/1949 |
| 69. | Leon Everitt | 4/21/1969 |
| 70. | Cy Falkenberg | 4/21/1903 |
| 71. | Duke Farrell | 4/21/1888 |
| 72. | Lou Fiene | 4/21/1906 |
| 73. | Pedro Figueroa | 4/21/2012 |
| 74. | Neal Finn | 4/21/1930 |
| 75. | Bill Fischer | 4/21/1956 |
| 76. | Red Fisher | 4/21/1910 |
| 77. | Hank Foiles | 4/21/1953 |
| 78. | Eric Fornataro | 4/21/2014 |
| 79. | Paul Foytack | 4/21/1953 |
| 80. | Len Gabrielson | 4/21/1939 |
| 81. | Phil Gallivan | 4/21/1931 |
| 82. | John Ganzel | 4/21/1898 |
| 83. | Floyd Giebell | 4/21/1939 |
| 84. | Cole Gillespie | 4/21/2010 |
| 85. | Jim Grant | 4/21/1923 |
| 86. | Bob Greenwood | 4/21/1954 |
| 87. | Ed Gremminger | 4/21/1895 |
| 88. | Kip Gross | 4/21/1990 |
| 89. | Ben Guintini | 4/21/1946 |
| 90. | Bud Hafey | 4/21/1935 |
| 91. | Ray Hale | 4/21/1902 |
| 92. | Raymond Haley | 4/21/1915 |
| 93. | John Hall | 4/21/1948 |
| 94. | Joe Hatten | 4/21/1946 |
| 95. | Arnold Hauser | 4/21/1910 |
| 96. | Drew Hayes | 4/21/2016 |
| 97. | Red Hayworth | 4/21/1944 |
| 98. | George Hemming | 4/21/1890 |
| 99. | Adrian Hernandez | 4/21/2001 |
| 100. | Steve Hertz | 4/21/1964 |
| 101. | Cliff Hill | 4/21/1917 |
| 102. | Joe Hoover | 4/21/1943 |
| 103. | Jim Hopper | 4/21/1946 |
| 104. | Drew Hutchison | 4/21/2012 |
| 105. | Hansel Izquierdo | 4/21/2002 |
| 106. | Lloyd Johnson | 4/21/1934 |
| 107. | Chris Jones | 4/21/1991 |
| 108. | Bob Kahle | 4/21/1938 |
| 109. | Jim Kane | 4/21/1908 |
| 110. | Dave Keefe | 4/21/1917 |
| 111. | Marty Keough | 4/21/1956 |
| 112. | Chad Kimsey | 4/21/1929 |
| 113. | Chris Kitsos | 4/21/1954 |
| 114. | Bobby Klaus | 4/21/1964 |
| 115. | Lou Klein | 4/21/1943 |
| 116. | Ron Kline | 4/21/1952 |
| 117. | Kurt Krieger | 4/21/1949 |
| 118. | Joe Lake | 4/21/1908 |
| 119. | Dale Long | 4/21/1951 |
| 120. | Bris Lord | 4/21/1905 |
| 121. | Russ Lyon | 4/21/1944 |
| 122. | Duke Maas | 4/21/1955 |
| 123. | Max Macon | 4/21/1938 |
| 124. | Woody Main | 4/21/1948 |
| 125. | Connie Marrero | 4/21/1950 |
| 126. | Fred Martin | 4/21/1946 |
| 127. | Joe Martin | 4/21/1936 |
| 128. | Merrill May | 4/21/1939 |
| 129. | William McCarthy | 4/21/1906 |
| 130. | Jim McCloskey | 4/21/1936 |
| 131. | Herm McFarland | 4/21/1896 |
| 132. | Tim McGinley | 4/21/1875 |
| 133. | Art McGovern | 4/21/1905 |
| 134. | Mike McNally | 4/21/1915 |
| 135. | Win Mercer | 4/21/1894 |
| 136. | Drew Meyer | 4/21/2006 |
| 137. | Cotton Minahan | 4/21/1907 |
| 138. | Joe Muir | 4/21/1951 |
| 139. | Red Murff | 4/21/1956 |
| 140. | Neal Musser | 4/21/2007 |
| 141. | Richie Myers | 4/21/1956 |
| 142. | Mike Nagy | 4/21/1969 |
| 143. | Joe Nathan | 4/21/1999 |
| 144. | Willie Norwood | 4/21/1977 |
| 145. | Ken O'Dea | 4/21/1935 |
| 146. | Jack O'Neill | 4/21/1902 |
| 147. | Brett Oberholtzer | 4/21/2013 |
| 148. | Joe Oeschger | 4/21/1914 |
| 149. | Fritz Ostermueller | 4/21/1934 |
| 150. | Erv Palica | 4/21/1945 |
| 151. | Fred Payne | 4/21/1906 |
| 152. | Paul Penson | 4/21/1954 |
| 153. | Lee Pfund | 4/21/1945 |
| 154. | Deacon Phillippe | 4/21/1899 |
| 155. | Hipolito Pichardo | 4/21/1992 |
| 156. | Kevin Plawecki | 4/21/2015 |
| 157. | Rance Pless | 4/21/1956 |
| 158. | Tot Pressnell | 4/21/1938 |
| 159. | Buddy Pritchard | 4/21/1957 |
| 160. | Pat Ragan | 4/21/1909 |
| 161. | Anthony Rendon | 4/21/2013 |
| 162. | Beryl Richmond | 4/21/1933 |
| 163. | Johnny Rigney | 4/21/1937 |
| 164. | Carlos Rodon | 4/21/2015 |
| 165. | Max Rosenfeld | 4/21/1931 |
| 166. | Phil Routcliffe | 4/21/1890 |
| 167. | Jorge Rubio | 4/21/1966 |
| 168. | Addison Russell | 4/21/2015 |
| 169. | Ed Samcoff | 4/21/1951 |
| 170. | Mort Scanlan | 4/21/1890 |
| 171. | Crazy Schmit | 4/21/1890 |
| 172. | Chuck Sheerin | 4/21/1936 |
| 173. | Jim Shilling | 4/21/1939 |
| 174. | Zack Short | 4/21/2021 |
| 175. | Roy Sievers | 4/21/1949 |
| 176. | Harry Simpson | 4/21/1951 |
| 177. | Dave Sisler | 4/21/1956 |
| 178. | Gordon Slade | 4/21/1930 |
| 179. | George Smith | 4/21/1926 |
| 180. | Ed Somerville | 4/21/1875 |
| 181. | By Speece | 4/21/1924 |
| 182. | Eddie Stanky | 4/21/1943 |
| 183. | Hank Steinbacher | 4/21/1937 |
| 184. | Scott Stratton | 4/21/1888 |
| 185. | Oscar Streit | 4/21/1899 |
| 186. | George Suggs | 4/21/1908 |
| 187. | Charlie Sullivan | 4/21/1928 |
| 188. | Chad Tracy | 4/21/2004 |
| 189. | George Trenwith | 4/21/1875 |
| 190. | Tom Urbani | 4/21/1993 |
| 191. | Rene Valdes | 4/21/1957 |
| 192. | Deacon Van Buren | 4/21/1904 |
| 193. | Tom Vickery | 4/21/1890 |
| 194. | Lee Walls | 4/21/1952 |
| 195. | Fred Warner | 4/21/1875 |
| 196. | Allen Webster | 4/21/2013 |
| 197. | Huyler Westervelt | 4/21/1894 |
| 198. | Lee Wheat | 4/21/1954 |
| 199. | Del Wilber | 4/21/1946 |
| 200. | Walt Williams | 4/21/1964 |
| 201. | Johnnie Williams | 4/21/1914 |
| 202. | Hooks Wiltse | 4/21/1904 |
| 203. | Lave Winham | 4/21/1902 |
| 204. | Emil Yde | 4/21/1924 |
| 205. | Harley Young | 4/21/1908 |
| 206. | Frankie Zak | 4/21/1944 |
| 207. | George Zuverink | 4/21/1951 |
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