59 MLB Players debut on July 22
| # | Player | debut Date |
|---|---|---|
| 1. | Abe Alvarez | 7/22/2004 |
| 2. | Norm Angelini | 7/22/1972 |
| 3. | Bob Babcock | 7/22/1979 |
| 4. | Grant Balfour | 7/22/2001 |
| 5. | Anthony Banda | 7/22/2017 |
| 6. | Lorenzo Barcelo | 7/22/2000 |
| 7. | Ed Barney | 7/22/1915 |
| 8. | Charley Bassett | 7/22/1884 |
| 9. | Jeff Beliveau | 7/22/2012 |
| 10. | Bob Blaylock | 7/22/1956 |
| 11. | John Boozer | 7/22/1962 |
| 12. | Ryan Bowen | 7/22/1991 |
| 13. | Gus Brittain | 7/22/1937 |
| 14. | Frank Chapman | 7/22/1887 |
| 15. | Dick Conway | 7/22/1886 |
| 16. | Jamie D'Antona | 7/22/2008 |
| 17. | Grant Dayton | 7/22/2016 |
| 18. | Miguel de la Hoz | 7/22/1960 |
| 19. | Frank Demaree | 7/22/1932 |
| 20. | Larry Doyle | 7/22/1907 |
| 21. | John Dyler | 7/22/1882 |
| 22. | George Elder | 7/22/1949 |
| 23. | Brad Eldred | 7/22/2005 |
| 24. | Steve Falteisek | 7/22/1997 |
| 25. | Sal Frelick | 7/22/2023 |
| 26. | Kason Gabbard | 7/22/2006 |
| 27. | Claude Gouzzie | 7/22/1903 |
| 28. | Buck Hopkins | 7/22/1907 |
| 29. | Jason Kipnis | 7/22/2011 |
| 30. | Brandon Laird | 7/22/2011 |
| 31. | Victor Mata | 7/22/1984 |
| 32. | Dave Maurer | 7/22/2000 |
| 33. | Jack McAdams | 7/22/1911 |
| 34. | Macay McBride | 7/22/2005 |
| 35. | Sergio Mitre | 7/22/2003 |
| 36. | John Newell | 7/22/1891 |
| 37. | Pat O'Connell | 7/22/1886 |
| 38. | Chad Qualls | 7/22/2004 |
| 39. | Rene Reyes | 7/22/2003 |
| 40. | Tom Ryder | 7/22/1884 |
| 41. | Jimmy Say | 7/22/1882 |
| 42. | Gary Serum | 7/22/1977 |
| 43. | Timothy Sheehan | 7/22/1895 |
| 44. | Jose Sosa | 7/22/1975 |
| 45. | Pussy Tebeau | 7/22/1895 |
| 46. | Ray Thomas | 7/22/1938 |
| 47. | Carlos Torres | 7/22/2009 |
| 48. | Erich Uelmen | 7/22/2022 |
| 49. | Jonathan Villar | 7/22/2013 |
| 50. | Josh Wall | 7/22/2012 |
| 51. | Forrest Wall | 7/22/2023 |
| 52. | Harry Weber | 7/22/1884 |
| 53. | Derrick White | 7/22/1993 |
| 54. | Bob Wicker | 7/22/1901 |
| 55. | Allan Winans | 7/22/2023 |
| 56. | Jackson Wolf | 7/22/2023 |
| 57. | Brad Woodall | 7/22/1994 |
| 58. | Dave Wright | 7/22/1895 |
| 59. | Barry Zito | 7/22/2000 |
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