83 MLB Players debut on August 21
| # | Player | debut Date |
|---|---|---|
| 1. | Paul Abbott | 8/21/1990 |
| 2. | Tavo Alvarez | 8/21/1995 |
| 3. | Grant Bowler | 8/21/1931 |
| 4. | Parker Bridwell | 8/21/2016 |
| 5. | Eude Brito | 8/21/2005 |
| 6. | Jose Butto | 8/21/2022 |
| 7. | Ben Caffyn | 8/21/1906 |
| 8. | Jim Campbell | 8/21/1990 |
| 9. | Ryan Church | 8/21/2004 |
| 10. | Bobby Clark | 8/21/1979 |
| 11. | Kyle Cody | 8/21/2020 |
| 12. | Roman Colon | 8/21/2004 |
| 13. | Juan Cruz | 8/21/2001 |
| 14. | Andy Cusick | 8/21/1884 |
| 15. | Tyler Cyr | 8/21/2022 |
| 16. | Ramon de los Santos | 8/21/1974 |
| 17. | Pat Deisel | 8/21/1902 |
| 18. | Bill Delaney | 8/21/1890 |
| 19. | Jason Dickson | 8/21/1996 |
| 20. | Red Dorman | 8/21/1928 |
| 21. | Steve Edlefsen | 8/21/2011 |
| 22. | Jerad Eickhoff | 8/21/2015 |
| 23. | George Ellison | 8/21/1920 |
| 24. | Nate Fisher | 8/21/2022 |
| 25. | Bill Fleming | 8/21/1940 |
| 26. | Jake Fraley | 8/21/2019 |
| 27. | Randy Gomez | 8/21/1984 |
| 28. | Wayne Gross | 8/21/1976 |
| 29. | Yuli Gurriel | 8/21/2016 |
| 30. | Bert Hall | 8/21/1911 |
| 31. | Jonathan Hernandez | 8/21/2019 |
| 32. | Mark Holzemer | 8/21/1993 |
| 33. | Mike Jacobs | 8/21/2005 |
| 34. | Travis Jankowski | 8/21/2015 |
| 35. | Mike Jeffcoat | 8/21/1983 |
| 36. | Nick Johnson | 8/21/2001 |
| 37. | Mike Jordan | 8/21/1890 |
| 38. | Adam Kennedy | 8/21/1999 |
| 39. | Michael Kirkman | 8/21/2010 |
| 40. | Brian Koelling | 8/21/1993 |
| 41. | Michael Kopech | 8/21/2018 |
| 42. | Dennis Lamp | 8/21/1977 |
| 43. | Ray Lankford | 8/21/1990 |
| 44. | Jack Leary | 8/21/1880 |
| 45. | Darren Lewis | 8/21/1990 |
| 46. | Ramon Lopez | 8/21/1966 |
| 47. | David Martinez | 8/21/2013 |
| 48. | Harry Morelock | 8/21/1891 |
| 49. | Ryan Mountcastle | 8/21/2020 |
| 50. | Floyd Newkirk | 8/21/1934 |
| 51. | Cristian Pache | 8/21/2020 |
| 52. | Dave Pavlas | 8/21/1990 |
| 53. | Joel Payamps | 8/21/2019 |
| 54. | Chick Pedroes | 8/21/1902 |
| 55. | Phil Plantier | 8/21/1990 |
| 56. | Walter Plock | 8/21/1891 |
| 57. | A. J. Puk | 8/21/2019 |
| 58. | Arthur Rhodes | 8/21/1991 |
| 59. | Ricardo Rodriguez | 8/21/2002 |
| 60. | JoJo Romero | 8/21/2020 |
| 61. | Chris Rusin | 8/21/2012 |
| 62. | Tim Salmon | 8/21/1992 |
| 63. | Jesus Sanchez | 8/21/2020 |
| 64. | Michael Schwimer | 8/21/2011 |
| 65. | Chris Snyder | 8/21/2004 |
| 66. | Nicklaus Snyder | 8/21/2021 |
| 67. | Greg Swindell | 8/21/1986 |
| 68. | Pat Tabler | 8/21/1981 |
| 69. | Live Oak Taylor | 8/21/1877 |
| 70. | Al Tesch | 8/21/1915 |
| 71. | Pat Tobin | 8/21/1941 |
| 72. | Mike Trost | 8/21/1890 |
| 73. | Harry Truby | 8/21/1895 |
| 74. | Trea Turner | 8/21/2015 |
| 75. | Dave Tyriver | 8/21/1962 |
| 76. | Framber Valdez | 8/21/2018 |
| 77. | Jeff Wallace | 8/21/1997 |
| 78. | Hooks Warner | 8/21/1916 |
| 79. | Steve Watkins | 8/21/2004 |
| 80. | Al Wickland | 8/21/1913 |
| 81. | Dean Wilkins | 8/21/1989 |
| 82. | Mike Wood | 8/21/2003 |
| 83. | Eric Yardley | 8/21/2019 |
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