65 MLB Players debut on August 25
| # | Player | debut Date |
|---|---|---|
| 1. | Benito Baez | 8/25/2001 |
| 2. | John Bates | 8/25/1889 |
| 3. | Sam Bowen | 8/25/1977 |
| 4. | Jim Breton | 8/25/1913 |
| 5. | Keith Brown | 8/25/1988 |
| 6. | Jim Bruske | 8/25/1995 |
| 7. | Billy Buckner | 8/25/2007 |
| 8. | Bob Burda | 8/25/1962 |
| 9. | Edward Cabrera | 8/25/2021 |
| 10. | Lew Camp | 8/25/1892 |
| 11. | Cisco Carlos | 8/25/1967 |
| 12. | Goat Cochran | 8/25/1915 |
| 13. | Gary Cooper | 8/25/1980 |
| 14. | Sam Covington | 8/25/1913 |
| 15. | John Curtiss | 8/25/2017 |
| 16. | Steve Davis | 8/25/1985 |
| 17. | Slow Joe Doyle | 8/25/1906 |
| 18. | Chone Figgins | 8/25/2002 |
| 19. | Don Fisher | 8/25/1945 |
| 20. | John Flavin | 8/25/1964 |
| 21. | Jeff Francis | 8/25/2004 |
| 22. | Armando Gabino | 8/25/2009 |
| 23. | Bob Gilks | 8/25/1887 |
| 24. | Joe Gonzales | 8/25/1937 |
| 25. | Alex Gonzalez | 8/25/1998 |
| 26. | Lenny Green | 8/25/1957 |
| 27. | Ken Griffey | 8/25/1973 |
| 28. | Jeff Hearron | 8/25/1985 |
| 29. | Jonah Heim | 8/25/2020 |
| 30. | Shoeless Joe Jackson | 8/25/1908 |
| 31. | Pete Johns | 8/25/1915 |
| 32. | Tom Jones | 8/25/1902 |
| 33. | Ed Keas | 8/25/1888 |
| 34. | Ed Killian | 8/25/1903 |
| 35. | Jake Latz | 8/25/2021 |
| 36. | Sean Lawrence | 8/25/1998 |
| 37. | Brian Lesher | 8/25/1996 |
| 38. | Nelson Liriano | 8/25/1987 |
| 39. | Radhames Liz | 8/25/2007 |
| 40. | Danny MacFayden | 8/25/1926 |
| 41. | Jerry McQuaig | 8/25/1934 |
| 42. | Travis Miller | 8/25/1996 |
| 43. | Willis Otanez | 8/25/1998 |
| 44. | Troy Patton | 8/25/2007 |
| 45. | Francisco Peguero | 8/25/2012 |
| 46. | Ed Pipgras | 8/25/1932 |
| 47. | Lou Possehl | 8/25/1946 |
| 48. | John Rainey | 8/25/1887 |
| 49. | Jeff Reardon | 8/25/1979 |
| 50. | Anthony Recker | 8/25/2011 |
| 51. | Lou Rochelli | 8/25/1944 |
| 52. | Trevor Rogers | 8/25/2020 |
| 53. | Skeeter Shelton | 8/25/1915 |
| 54. | Ryan Sherriff | 8/25/2017 |
| 55. | Craig Stansberry | 8/25/2007 |
| 56. | Denny Sullivan | 8/25/1879 |
| 57. | Tomas Telis | 8/25/2014 |
| 58. | Blaine Thomas | 8/25/1911 |
| 59. | Ira Townsend | 8/25/1920 |
| 60. | Terry Turner | 8/25/1901 |
| 61. | Jim Walsh | 8/25/1921 |
| 62. | Frank Wayenberg | 8/25/1924 |
| 63. | Greg Weissert | 8/25/2022 |
| 64. | Ron Witmeyer | 8/25/1991 |
| 65. | Eric Young | 8/25/2009 |
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