136 MLB Players debut on September 21
| # | Player | debut Date |
|---|---|---|
| 1. | Fritz Ackley | 9/21/1963 |
| 2. | Jorge Alcala | 9/21/2019 |
| 3. | Tucker Ashford | 9/21/1976 |
| 4. | Carlos Asuaje | 9/21/2016 |
| 5. | King Bailey | 9/21/1895 |
| 6. | Home Run Baker | 9/21/1908 |
| 7. | Jim Ball | 9/21/1907 |
| 8. | Dick Bass | 9/21/1939 |
| 9. | Jodie Beeler | 9/21/1944 |
| 10. | Joe Blanton | 9/21/2004 |
| 11. | Cecil Bolton | 9/21/1928 |
| 12. | King Brady | 9/21/1905 |
| 13. | Will Brennan | 9/21/2022 |
| 14. | Bert Brenner | 9/21/1912 |
| 15. | Jophery Brown | 9/21/1968 |
| 16. | Keon Broxton | 9/21/2015 |
| 17. | Bill Buckner | 9/21/1969 |
| 18. | Josh Butler | 9/21/2009 |
| 19. | George Chalmers | 9/21/1910 |
| 20. | Darrin Chapin | 9/21/1991 |
| 21. | Harry Chozen | 9/21/1937 |
| 22. | Eucal Clanton | 9/21/1922 |
| 23. | Jim Coates | 9/21/1956 |
| 24. | Dylan Coleman | 9/21/2021 |
| 25. | Jackie Collum | 9/21/1951 |
| 26. | Tyler Colvin | 9/21/2009 |
| 27. | Bill Conroy | 9/21/1935 |
| 28. | Lou Criger | 9/21/1896 |
| 29. | Francisco Cruceta | 9/21/2004 |
| 30. | Gene Curtis | 9/21/1903 |
| 31. | Chuck Daniel | 9/21/1957 |
| 32. | Ike Danning | 9/21/1928 |
| 33. | Harry Davis | 9/21/1895 |
| 34. | George Dickey | 9/21/1935 |
| 35. | Art Doll | 9/21/1935 |
| 36. | Logan Drake | 9/21/1922 |
| 37. | Bill Duzen | 9/21/1890 |
| 38. | Duffy Dyer | 9/21/1968 |
| 39. | Cam Eden | 9/21/2023 |
| 40. | Sherman Edwards | 9/21/1934 |
| 41. | Mike Esposito | 9/21/2005 |
| 42. | Turk Farrell | 9/21/1956 |
| 43. | Mike Fiore | 9/21/1968 |
| 44. | Tyler Fitzgerald | 9/21/2023 |
| 45. | Sam Frock | 9/21/1907 |
| 46. | Ralph Gagliano | 9/21/1965 |
| 47. | Frank Gatins | 9/21/1898 |
| 48. | Tom Gettinger | 9/21/1889 |
| 49. | Norman Glaser | 9/21/1920 |
| 50. | Larry Gowell | 9/21/1972 |
| 51. | Jerry Grote | 9/21/1963 |
| 52. | Doc Hamann | 9/21/1922 |
| 53. | Brenan Hanifee | 9/21/2023 |
| 54. | Frankie Hayes | 9/21/1933 |
| 55. | Kelvin Herrera | 9/21/2011 |
| 56. | Chris Howard | 9/21/1993 |
| 57. | Charlie Johnson | 9/21/1908 |
| 58. | Jimmy Jones | 9/21/1986 |
| 59. | Herb Kelly | 9/21/1914 |
| 60. | Lynn King | 9/21/1935 |
| 61. | Rudy Kling | 9/21/1902 |
| 62. | Rudy Kneisch | 9/21/1926 |
| 63. | Emil Kush | 9/21/1941 |
| 64. | Art Kusnyer | 9/21/1970 |
| 65. | Bob Kuzava | 9/21/1946 |
| 66. | Don Lassetter | 9/21/1957 |
| 67. | Brandon League | 9/21/2004 |
| 68. | Dave Leonhard | 9/21/1967 |
| 69. | Dennis Lewallyn | 9/21/1975 |
| 70. | Hans Lobert | 9/21/1903 |
| 71. | Henry Lynch | 9/21/1893 |
| 72. | John Malarkey | 9/21/1894 |
| 73. | Manuel Margot | 9/21/2016 |
| 74. | Harry Maskrey | 9/21/1882 |
| 75. | Denny McLain | 9/21/1963 |
| 76. | Jim McManus | 9/21/1960 |
| 77. | Joe Mellana | 9/21/1927 |
| 78. | Fred Merkle | 9/21/1907 |
| 79. | Pat Misch | 9/21/2006 |
| 80. | Dave Moates | 9/21/1974 |
| 81. | Bengie Molina | 9/21/1998 |
| 82. | Jim Moore | 9/21/1928 |
| 83. | Lew Moren | 9/21/1903 |
| 84. | Joe Morgan | 9/21/1963 |
| 85. | Colt Morton | 9/21/2007 |
| 86. | Trot Nixon | 9/21/1996 |
| 87. | Joe Nolan | 9/21/1972 |
| 88. | Fred Norman | 9/21/1962 |
| 89. | Marty O'Toole | 9/21/1908 |
| 90. | Jared Oliva | 9/21/2020 |
| 91. | Jack Owens | 9/21/1935 |
| 92. | Karl Pagel | 9/21/1978 |
| 93. | Emilio Palmero | 9/21/1915 |
| 94. | Dode Paskert | 9/21/1907 |
| 95. | Glen Perkins | 9/21/2006 |
| 96. | Rico Petrocelli | 9/21/1963 |
| 97. | Leo Posada | 9/21/1960 |
| 98. | Lew Post | 9/21/1902 |
| 99. | Don Prince | 9/21/1962 |
| 100. | Harlan Pyle | 9/21/1928 |
| 101. | Charlie Rabe | 9/21/1957 |
| 102. | Joe Regan | 9/21/1898 |
| 103. | Hunter Renfroe | 9/21/2016 |
| 104. | John Ricks | 9/21/1891 |
| 105. | Charlie Ritter | 9/21/1885 |
| 106. | Henry Rodriguez | 9/21/2009 |
| 107. | Wilfredo Rodriguez | 9/21/2001 |
| 108. | Jim Romano | 9/21/1950 |
| 109. | Marc Ronan | 9/21/1993 |
| 110. | Rosie Rosebraugh | 9/21/1898 |
| 111. | Don Rudolph | 9/21/1957 |
| 112. | Jeff Schattinger | 9/21/1981 |
| 113. | Frank Schulte | 9/21/1904 |
| 114. | Ray Shore | 9/21/1946 |
| 115. | Brian Simmons | 9/21/1998 |
| 116. | Ted Simmons | 9/21/1968 |
| 117. | Dick Simpson | 9/21/1962 |
| 118. | Harry Smith | 9/21/1914 |
| 119. | Don Songer | 9/21/1924 |
| 120. | Ricky Stone | 9/21/2001 |
| 121. | Hughie Tate | 9/21/1905 |
| 122. | Jeff Terpko | 9/21/1974 |
| 123. | Roy Thomas | 9/21/1977 |
| 124. | Jocko Thompson | 9/21/1948 |
| 125. | Jim Traber | 9/21/1984 |
| 126. | Harry Vahrenhorst | 9/21/1904 |
| 127. | Cory Vance | 9/21/2002 |
| 128. | Al Veigel | 9/21/1939 |
| 129. | Rube Vickers | 9/21/1902 |
| 130. | Pete Ward | 9/21/1962 |
| 131. | Colin Ward | 9/21/1985 |
| 132. | Mike White | 9/21/1963 |
| 133. | Dan Winkler | 9/21/2015 |
| 134. | Red Witt | 9/21/1957 |
| 135. | Bob Wright | 9/21/1915 |
| 136. | Jim York | 9/21/1970 |
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