21 MLB Players debut in 1881
| # | Player | debut Date |
|---|---|---|
| 1. | Pat Deasley | 5/18/1881 |
| 2. | Jerry Denny | 5/2/1881 |
| 3. | George Derby | 5/2/1881 |
| 4. | Martin Flaherty | 8/18/1881 |
| 5. | John Fox | 6/2/1881 |
| 6. | Fred Lewis | 7/2/1881 |
| 7. | Jack Lynch | 5/2/1881 |
| 8. | John Morrissey | 5/2/1881 |
| 9. | Tony Mullane | 8/27/1881 |
| 10. | Henry Myers | 8/20/1881 |
| 11. | Hugh Nicol | 5/3/1881 |
| 12. | Andy Piercy | 5/12/1881 |
| 13. | Martin Powell | 6/18/1881 |
| 14. | Joseph Quinn | 9/7/1881 |
| 15. | Asa Stratton | 6/17/1881 |
| 16. | Sleeper Sullivan | 5/3/1881 |
| 17. | Ed Swartwood | 8/11/1881 |
| 18. | Billy Taylor | 5/21/1881 |
| 19. | Dasher Troy | 8/23/1881 |
| 20. | Jim Whitney | 5/2/1881 |
| 21. | Sam Wise | 7/30/1881 |
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