119 MLB Players debut in 1921
| # | Player | debut Date |
|---|---|---|
| 1. | Sam Barnes | 9/14/1921 |
| 2. | Bill Barrett | 5/13/1921 |
| 3. | Petie Behan | 9/16/1921 |
| 4. | Joe Berry | 7/18/1921 |
| 5. | Red Bird | 9/17/1921 |
| 6. | Bill Bishop | 9/15/1921 |
| 7. | Lu Blue | 4/14/1921 |
| 8. | Fred Bratschi | 7/24/1921 |
| 9. | Garland Braxton | 5/27/1921 |
| 10. | Frank Brazill | 4/13/1921 |
| 11. | Frank Bruggy | 4/13/1921 |
| 12. | Frank Callaway | 9/17/1921 |
| 13. | Lefty Clarke | 10/2/1921 |
| 14. | Bert Cole | 4/19/1921 |
| 15. | Sarge Connally | 9/10/1921 |
| 16. | Joe Connolly | 10/1/1921 |
| 17. | Johnny Cooney | 4/19/1921 |
| 18. | Bill Cunningham | 7/14/1921 |
| 19. | Kiki Cuyler | 9/29/1921 |
| 20. | Lum Davenport | 5/3/1921 |
| 21. | Sam Dodge | 9/24/1921 |
| 22. | Pete Donohue | 7/1/1921 |
| 23. | Astyanax Douglass | 7/30/1921 |
| 24. | Carter Elliott | 9/10/1921 |
| 25. | Reuben Ewing | 6/21/1921 |
| 26. | Horace Fenner | 9/9/1921 |
| 27. | Lew Fonseca | 4/13/1921 |
| 28. | George Foss | 4/16/1921 |
| 29. | Harvey Freeman | 7/10/1921 |
| 30. | Buck Freeman | 4/13/1921 |
| 31. | Oscar Fuhr | 4/19/1921 |
| 32. | Dot Fulghum | 9/15/1921 |
| 33. | Curt Fullerton | 4/14/1921 |
| 34. | Nemo Gaines | 6/26/1921 |
| 35. | Johnny Gooch | 9/9/1921 |
| 36. | Ray Gordinier | 9/17/1921 |
| 37. | Goose Goslin | 9/16/1921 |
| 38. | Ollie Hanson | 4/27/1921 |
| 39. | Chicken Hawks | 4/14/1921 |
| 40. | Bud Heine | 10/1/1921 |
| 41. | Bernie Henderson | 9/5/1921 |
| 42. | Butch Henline | 4/13/1921 |
| 43. | Dutch Henry | 9/15/1921 |
| 44. | Kenny Hogan | 10/2/1921 |
| 45. | Carl Holling | 4/19/1921 |
| 46. | Bill Hughes | 9/15/1921 |
| 47. | Walt Irwin | 4/24/1921 |
| 48. | Tex Jeanes | 4/20/1921 |
| 49. | Howie Jones | 9/5/1921 |
| 50. | Claude Jonnard | 10/1/1921 |
| 51. | Tony Kaufmann | 9/23/1921 |
| 52. | Joe Klugmann | 9/23/1921 |
| 53. | Ray Kolp | 4/16/1921 |
| 54. | Wally Kopf | 10/1/1921 |
| 55. | George Lees | 5/7/1921 |
| 56. | Elmer Leifer | 9/7/1921 |
| 57. | Jim Mahady | 10/2/1921 |
| 58. | Ben Mallonee | 9/14/1921 |
| 59. | Vance McIlree | 9/13/1921 |
| 60. | Doug McWeeny | 4/24/1921 |
| 61. | Herm Merritt | 8/24/1921 |
| 62. | John Michaelson | 8/28/1921 |
| 63. | Ralph Miller | 9/16/1921 |
| 64. | Bing Miller | 4/16/1921 |
| 65. | Ray Miner | 9/15/1921 |
| 66. | Johnny Mitchell | 5/21/1921 |
| 67. | Johnny Mokan | 4/15/1921 |
| 68. | John Monroe | 4/16/1921 |
| 69. | Cy Morgan | 6/8/1921 |
| 70. | Phil Morrison | 9/30/1921 |
| 71. | Dominic Mulrenan | 4/24/1921 |
| 72. | Ernie Neitzke | 6/2/1921 |
| 73. | Charlie Niebergall | 6/17/1921 |
| 74. | Ted Odenwald | 4/13/1921 |
| 75. | Red Ostergard | 6/14/1921 |
| 76. | Frank Parkinson | 4/13/1921 |
| 77. | Slicker Parks | 7/11/1921 |
| 78. | Pat Patterson | 4/14/1921 |
| 79. | Russell Pence | 5/13/1921 |
| 80. | Jack Perrin | 7/11/1921 |
| 81. | Jesse Petty | 4/14/1921 |
| 82. | Clarke Pittenger | 4/15/1921 |
| 83. | Frank Pratt | 5/13/1921 |
| 84. | Drew Rader | 7/18/1921 |
| 85. | Goldie Rapp | 4/13/1921 |
| 86. | Lance Richbourg | 7/4/1921 |
| 87. | Jim Riley | 7/3/1921 |
| 88. | Tink Riviere | 4/15/1921 |
| 89. | Ray Rohwer | 4/13/1921 |
| 90. | Joe Sargent | 4/27/1921 |
| 91. | Duke Sedgwick | 7/12/1921 |
| 92. | Luke Sewell | 6/30/1921 |
| 93. | Earl Sheely | 4/14/1921 |
| 94. | Ginger Shinault | 7/4/1921 |
| 95. | Bill Skiff | 5/17/1921 |
| 96. | Riggs Stephenson | 4/13/1921 |
| 97. | Lefty Stewart | 4/20/1921 |
| 98. | Luke Stuart | 7/28/1921 |
| 99. | George Stueland | 9/15/1921 |
| 100. | Jim Sullivan | 9/27/1921 |
| 101. | Suds Sutherland | 4/14/1921 |
| 102. | Jackie Tavener | 9/24/1921 |
| 103. | Arlas Taylor | 9/15/1921 |
| 104. | Red Thomas | 9/13/1921 |
| 105. | Lee Thompson | 9/4/1921 |
| 106. | George Toporcer | 4/13/1921 |
| 107. | Cy Twombly | 6/25/1921 |
| 108. | Jim Walsh | 8/25/1921 |
| 109. | Bill Warwick | 7/18/1921 |
| 110. | Rip Wheeler | 9/30/1921 |
| 111. | Jack Wieneke | 7/4/1921 |
| 112. | Denny Williams | 4/15/1921 |
| 113. | Mike Wilson | 6/4/1921 |
| 114. | Kettle Wirts | 7/20/1921 |
| 115. | Walter Wolf | 7/4/1921 |
| 116. | Yam Yaryan | 4/23/1921 |
| 117. | Moses Yellow Horse | 4/15/1921 |
| 118. | Elmer Yoter | 9/9/1921 |
| 119. | Walter Zink | 7/6/1921 |
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