62 MLB Players debut on May 22
| # | Player | debut Date |
|---|---|---|
| 1. | Tony Abreu | 5/22/2007 |
| 2. | Willy Adames | 5/22/2018 |
| 3. | Dan Adams | 5/22/1914 |
| 4. | Wally Andrews | 5/22/1884 |
| 5. | Graham Ashcraft | 5/22/2022 |
| 6. | Jeff Baldwin | 5/22/1990 |
| 7. | Henry Baldwin | 5/22/1927 |
| 8. | Red Barbary | 5/22/1943 |
| 9. | Brooks Brown | 5/22/2014 |
| 10. | Kole Calhoun | 5/22/2012 |
| 11. | Ernie Camacho | 5/22/1980 |
| 12. | Bill Clemensen | 5/22/1939 |
| 13. | Chris Colabello | 5/22/2013 |
| 14. | Jim Converse | 5/22/1993 |
| 15. | George Crosby | 5/22/1884 |
| 16. | Ed Delahanty | 5/22/1888 |
| 17. | Dayan Diaz | 5/22/2016 |
| 18. | Brandon Dixon | 5/22/2018 |
| 19. | Matt Duffy | 5/22/2014 |
| 20. | Nolan Fontana | 5/22/2017 |
| 21. | Pud Galvin | 5/22/1875 |
| 22. | Justin Germano | 5/22/2004 |
| 23. | George Gillpatrick | 5/22/1898 |
| 24. | Zack Greinke | 5/22/2004 |
| 25. | Lou Hardie | 5/22/1884 |
| 26. | Brett Hayes | 5/22/2009 |
| 27. | Jamie Hoffmann | 5/22/2009 |
| 28. | Edwin Hurtado | 5/22/1995 |
| 29. | Josh Judy | 5/22/2011 |
| 30. | Henry Kappel | 5/22/1887 |
| 31. | David Lee | 5/22/1999 |
| 32. | Joe Lefebvre | 5/22/1980 |
| 33. | John Lovett | 5/22/1903 |
| 34. | Tyler Lyons | 5/22/2013 |
| 35. | Anastacio Martinez | 5/22/2004 |
| 36. | Eddie Mayo | 5/22/1936 |
| 37. | Pryor McBee | 5/22/1926 |
| 38. | Brandon McCarthy | 5/22/2005 |
| 39. | Jim McLeod | 5/22/1930 |
| 40. | Pat McManus | 5/22/1879 |
| 41. | Carlos Mendez | 5/22/2003 |
| 42. | Lemmie Miller | 5/22/1984 |
| 43. | Joe Panik | 5/22/2014 |
| 44. | Ben Paulsen | 5/22/2014 |
| 45. | Mark Prior | 5/22/2002 |
| 46. | Cory Rasmus | 5/22/2013 |
| 47. | Danny Richardson | 5/22/1884 |
| 48. | Jay Rogers | 5/22/1914 |
| 49. | Lou Rosenberg | 5/22/1923 |
| 50. | Steve Springer | 5/22/1990 |
| 51. | George Stallings | 5/22/1890 |
| 52. | Billy Sunday | 5/22/1883 |
| 53. | Andrew Susac | 5/22/2014 |
| 54. | Dale Thayer | 5/22/2009 |
| 55. | Dickie Thon | 5/22/1979 |
| 56. | Ben Tincup | 5/22/1914 |
| 57. | Bobby Trevino | 5/22/1968 |
| 58. | Don Wakamatsu | 5/22/1991 |
| 59. | Taylor Walls | 5/22/2021 |
| 60. | Johnny Welch | 5/22/1926 |
| 61. | Bill Wertz | 5/22/1993 |
| 62. | Billy West | 5/22/1874 |
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