63 MLB Players debut on May 25
| # | Player | debut Date |
|---|---|---|
| 1. | Marcos Armas | 5/25/1993 |
| 2. | Tex Aulds | 5/25/1947 |
| 3. | Steve Baker | 5/25/1978 |
| 4. | Reggie Baldwin | 5/25/1978 |
| 5. | Scott Bankhead | 5/25/1986 |
| 6. | Denny Bautista | 5/25/2004 |
| 7. | Alex Beam | 5/25/1889 |
| 8. | Ryan Braun | 5/25/2007 |
| 9. | Glenn Brummer | 5/25/1981 |
| 10. | Mack Burk | 5/25/1956 |
| 11. | Jim Callahan | 5/25/1902 |
| 12. | Paul Carey | 5/25/1993 |
| 13. | Frank Carpin | 5/25/1965 |
| 14. | Keith Creel | 5/25/1982 |
| 15. | Art Daney | 5/25/1928 |
| 16. | Yerry De Los Santos | 5/25/2022 |
| 17. | Juan Diaz | 5/25/2012 |
| 18. | Andy Dominique | 5/25/2004 |
| 19. | Tom Evers | 5/25/1882 |
| 20. | George Frazier | 5/25/1978 |
| 21. | Steve Gajkowski | 5/25/1998 |
| 22. | Raul Gonzalez | 5/25/2000 |
| 23. | Jack Hannahan | 5/25/2006 |
| 24. | Aaron Harang | 5/25/2002 |
| 25. | Corey Hart | 5/25/2004 |
| 26. | Frank Hiller | 5/25/1946 |
| 27. | Mul Holland | 5/25/1926 |
| 28. | Tom Hume | 5/25/1977 |
| 29. | Bobby Keppel | 5/25/2006 |
| 30. | Clayton Kershaw | 5/25/2008 |
| 31. | Jeff Kobernus | 5/25/2013 |
| 32. | Dinelson Lamet | 5/25/2017 |
| 33. | Luis Leal | 5/25/1980 |
| 34. | Jacob Lindgren | 5/25/2015 |
| 35. | Dixon Machado | 5/25/2015 |
| 36. | Shane Mack | 5/25/1987 |
| 37. | Willie Mays | 5/25/1951 |
| 38. | Bill McCloskey | 5/25/1875 |
| 39. | Bob Melvin | 5/25/1985 |
| 40. | Ramiro Mendoza | 5/25/1996 |
| 41. | Orber Moreno | 5/25/1999 |
| 42. | Luke Nelson | 5/25/1919 |
| 43. | Ray Olmedo | 5/25/2003 |
| 44. | Mike Paxton | 5/25/1977 |
| 45. | Joel Peralta | 5/25/2005 |
| 46. | Chris Petersen | 5/25/1999 |
| 47. | Rob Radlosky | 5/25/1999 |
| 48. | Elizardo Ramirez | 5/25/2004 |
| 49. | Mike Regan | 5/25/1917 |
| 50. | Saul Rivera | 5/25/2006 |
| 51. | Sonny Ruberto | 5/25/1969 |
| 52. | Carey Selph | 5/25/1929 |
| 53. | Josh Smith | 5/25/2019 |
| 54. | Edgar Smith | 5/25/1883 |
| 55. | Chris Snelling | 5/25/2002 |
| 56. | Brian Snyder | 5/25/1985 |
| 57. | Bud Souchock | 5/25/1946 |
| 58. | Blake Tekotte | 5/25/2011 |
| 59. | Charlie Waitt | 5/25/1875 |
| 60. | Duane Walker | 5/25/1982 |
| 61. | Mike Yastrzemski | 5/25/2019 |
| 62. | Mike Zagurski | 5/25/2007 |
| 63. | Seby Zavala | 5/25/2019 |
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